Effect of 4-Hydroxy-2-Nonenal Modification on -Synuclein Aggregation
نویسندگان
چکیده
Several observations have implicated oxidative stress and aggregation of the presynaptic protein-synuclein in the pathogenesis of PD.-Synuclein has been shown to have affinity for unsaturated fatty acids and membranes enriched in PUFAs, which are especially sensitive to oxidation under conditions of oxidative stress. One of the most important products of lipid oxidation is 4-hydroxynonenal (HNE), which has been implicated in the pathogenesis of Parkinson’s disease. Consequently we investigated the effects of the interaction of HNE with-synuclein.
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